張貼者:2010年6月11日 中午12:53service orderble
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未知的使用者 已於 2011年5月10日 晚上8:13 更新
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 ADME Database provides the latest and most comprehensive data on interactions of substances with Drug Metabolizing Enzymes and Drug Transporters that are specific to humans. It is designed for use in drug research and development, including drug-drug interactions and ADME(Absorption, Distribution, Metabolism and Excretion) studies. The contents of the database were collected and organized by Professor Slobodan Rendic from Croatia. -------------------------------------- 開發商:Fujitsu Kyushu Systems Limited 原廠網址:http://jp.fujitsu.com/group/kyushu/services/lifescience/english/asp/admedb/
更新日期:2011/05/11 採購正式版、大量授權報價、技術支援、軟體諮詢、委託採購、詢問報價請來電 02-29299388 分機16 , 來信service@orderble.com,或 點我------------------------------------------------------------------------------
FeaturesHuman Drug Metabolizing Enzyme Database - Contains information on CYP enzymes and a number of variants, which participate/are tested in the metabolism of xenobiotics and endobiotics in humans.
- Contains information on substances (as well as a number of natural products and other factors) influencing CYP activity based on the following type of interactions:
 - Substrate
- Inhibitor
- Inducer
- Activator
- Contains information on the following enzymes:
 - Esterases
- UDP-glucuronosyltransferases
- Sulfotransferases
- Glutathione S-transferases
- Flavin-containing Monooxygenases
Kinetics Information Database(1)
 - Contains supporting entries for the Human Drug Metabolizing Enzyme Database, providing numerical data on major kinetic parameters relevant for use in drug development/application studies.
 - in vitro assay used
- Km
- Vmax
- Ki
- K_inactivation
- Cooperativity(n)
- IC50
- EC50
- T1/2
(1) Kinetic Database is available only when it is coupled with Human Drug Metabolizing Enzyme Database. |  | Human Drug Transporter Database
 - Contains information on transporters involved in transport of drugs, physiological compounds, nutrients, and other chemicals and metabolites.
 - ABC Transporters
- Organic Ion Transporters
- Peptide Transporters
- Nucleotide Transporters
- etc...
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Number of EntriesDatabase | Drug Metabolizing Enzymes | Transporters |
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P450 | Other Enzymes |
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Substrates | 23,577 | 5,111 | 8,519 | Inhibitors | 17,686 | 2,874 | 10,617 | Activator | 856 | 236 | 298 | Inducers | 6,444 | 715 | 1,027 |
Data as of April 2010 Data will be updated quarterly. |
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