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ADME database

張貼者:2010年6月11日 下午12:53service orderble   [ eddie liu 已於 2011年5月10日 下午8:13 更新 ]
ADME Database

ADME Database provides the latest and most comprehensive data on interactions of substances with Drug Metabolizing Enzymes and Drug Transporters that are specific to humans. It is designed for use in drug research and development, including drug-drug interactions and ADME(Absorption, Distribution, Metabolism and Excretion) studies. The contents of the database were collected and organized by Professor Slobodan Rendic from Croatia.

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開發商:Fujitsu Kyushu Systems Limited
原廠網址:http://jp.fujitsu.com/group/kyushu/services/lifescience/english/asp/admedb/
更新日期:2011/05/11
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Features

Human Drug Metabolizing Enzyme Database

  • Cytochrome P450
  • Contains information on CYP enzymes and a number of variants, which participate/are tested in the metabolism of xenobiotics and endobiotics in humans.
  • Contains information on substances (as well as a number of natural products and other factors) influencing CYP activity based on the following type of interactions:
    • Substrate
    • Inhibitor
    • Inducer
    • Activator
  • Other Enzymes
  • Contains information on the following enzymes:
    • Esterases
    • UDP-glucuronosyltransferases
    • Sulfotransferases
    • Glutathione S-transferases
    • Flavin-containing Monooxygenases
Kinetics Information Database(1)
  • Contains supporting entries for the Human Drug Metabolizing Enzyme Database, providing numerical data on major kinetic parameters relevant for use in drug development/application studies.
    • in vitro assay used
    • Km
    • Vmax
    • Ki
    • K_inactivation
    • Cooperativity(n)
    • IC50
    • EC50
    • T1/2
(1) Kinetic Database is available only when it is coupled with Human Drug Metabolizing Enzyme Database.
ADME DB overview

Human Drug Transporter Database
  • Contains information on transporters involved in transport of drugs, physiological compounds, nutrients, and other chemicals and metabolites.
    • ABC Transporters
    • Organic Ion Transporters
    • Peptide Transporters
    • Nucleotide Transporters
    • etc...

Number of Entries

DatabaseDrug Metabolizing EnzymesTransporters
P450Other Enzymes
Substrates23,5775,1118,519
Inhibitors17,6862,87410,617
Activator856236298
Inducers6,4447151,027

Data as of April 2010
Data will be updated quarterly.

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